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Thermo Scientific™

GeneBLAzer™ EDNRA-NFAT-bla HEK 293T Cells

Catalog number:  K1726

Related applications:

Pharma & Biopharma

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GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells contain the human Endothelin Type A Recpetor (EDNRA) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line. CellSensor™ NFAT-bla HEK293T cells (Cat. no. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of ET-1. In addition, GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The ENDRA receptor mediates signaling of endothelin proteins that regulate several critical biological processes, including development and function of blood vessels, production of certain hormones, and stimulation of cell growth and division. Defects in EDNRA-mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension, and cardiovascular disorders.

For Research Use Only. Not for use in diagnostic procedures.


Accession Number: NM_001957
Assay Entry: Cell-based beta lactamase reporter gene
Cell Line: 293 T (HEK)
Cell State: Dividing Cells
Detection Method: Fluorescent
Druggable Target: GPCRs
Gene Symbol: EDNRA
Population Status: Single Cell Clone Origin
Product Line: GeneBLAzer™
Reporter Gene: BLA (Beta-Lactamase)
System Type: GeneBLAzer™
Target Entry: EDNRA
Technique: FRET

Contents & storage

K1726 GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells
(LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
• GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells
• GeneBLAzer™ EDNRA-NFAT-bla HEK293T Assay Protocol
• Certificate of Analysis

The GeneBLAzer™ EDNRA-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.