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GeneBLAzer® M5-NFAT-bla CHO-K1 Cells

Catalog number: K1728

 Related applications: Pharma & Biopharma | Target & Lead Identification & Validation

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GeneBLAzer® M5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (Muscarinic) Receptor 5 (M5) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer® M5-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Carbachol. In addition, GeneBLAzer® M5-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Muscarinic acetylcholine receptor subtype 5 (M5) has an unknown physiological relevance primarily because of low expression levels and the lack of M5 receptor-selective ligands. However, knockout studies have suggested that M5 is involved in modulation of central dopamine function and the tone of cerebral blood vessels.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.


System: GeneBLAzer®
Reporter: BLA (Beta-Lactamase)
Cell Line: CHO-K1
Technique: FRET
Cell State: Dividing Cells
Gene Symbol: CHRM5
Product Size: 2 x 106 cells
Accession Number: BC041805.1
Detection Method: Fluorescent
Druggable Target: GPCRs
Population Status: Single Cell Clone Origin
Shipping Condition: Room Temperature

Contents & storage

K1728 GeneBLAzer® M5-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
• GeneBLAzer® M5-NFAT-bla CHO-K1 cells
• GeneBLAzer® M5-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis

The GeneBLAzer® M5-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.


Manuals & protocols