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GeneBLAzer® M5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (Muscarinic) Receptor 5 (M5) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer® M5-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Carbachol. In addition, GeneBLAzer® M5-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
Muscarinic acetylcholine receptor subtype 5 (M5) has an unknown physiological relevance primarily because of low expression levels and the lack of M5 receptor-selective ligands. However, knockout studies have suggested that M5 is involved in modulation of central dopamine function and the tone of cerebral blood vessels.
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Cell-based beta lactamase reporter gene
For Use With (Application)
Single Cell Clone Origin
Contents & Storage
Contents: K1728 GeneBLAzer™ M5-NFAT-bla CHO-K1 cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • GeneBLAzer™ M5-NFAT-bla CHO-K1 cells • GeneBLAzer™ M5-NFAT-bla CHO-K1 Assay Protocol • Certificate of Analysis
Storage: The GeneBLAzer™ M5-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.