Thermo Scientific™

GeneBLAzer™ MC4R-CRE-bla CHO-K1 Cells

Catalog number: K1738
Thermo Scientific™

GeneBLAzer™ MC4R-CRE-bla CHO-K1 Cells

Catalog number: K1738
Catalog Number
K1738
Unit Size
2 × 10^6 cells
Price (USD)
Price: 9,190.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
K17382 × 10^6 cells
Price: 9,190.00
Your Price:
-
Product Overview
Figures
Videos
Recommendations
Recommendations
Documents
FAQ
Citations & References
Additional Information
Recommendations
GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 4 (MC4R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of α MSH In addition, GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

MC4 receptors are expressed almost exclusively in the CNS and bind all of the melanocortin peptides, but only have high affinity for α-MSH and ACTH. The agouti peptide binds to the MC4R receptor with high affinity in in vitro tests but, being normally expressed only in skin, doesn't have access to the MC4R receptor under physiological conditions. The AGRP peptide is a high-affinity antagonist of the neural MC4R receptor. The MC4R receptor is involved in the regulation of energy homeostasis and erectile function.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NM_005912
Assay Entry
Cell-based beta lactamase reporter gene
Cell State
Dividing Cells
Detection Method
Fluorescent
For Use With (Application)
FRET
Gene Symbol
MC4R
Population Status
Single Cell Clone Origin
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Target Entry
MC4R
Cell Line
CHO-K1
System Type
GeneBLAzer™
Druggable Target
GPCRs

Contents & Storage

Contents:
K1738 GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells
• GeneBLAzer™ MC4R-CRE-bla CHO-K1 Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer™ MC4R-CRE-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.