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Thermo Scientific™

GeneBLAzer™ MC3R-CRE-bla CHO-K1 Cells

Catalog number: K1744
Thermo Scientific™

GeneBLAzer™ MC3R-CRE-bla CHO-K1 Cells

Catalog number: K1744
Catalog Number
K1744
Unit Size
2 x 106 cells
Price (USD)
8,140.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
K17442 x 106 cells
8,140.00
Your Price:
***
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GeneBLAzer® MC3R CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 3 (MC3R) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer® MC3R CRE-bla CHO-K1 DA cells are functionally validated for Z' and EC50 concentrations of NDP-α-MSH. In addition, GeneBLAzer® MC3R CRE-bla CHO-K1 DA cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The melanocortin-3 receptor (MC3R) is primarily expressed in the hypothalamus, and plays an important role in the regulation of energy homeostasis. MC3R recognizes all of the melanocortin peptides, and notably binds - -MSH with greater affinity than the other melanocortin receptors. MC3R-deficient (MC3R-/-) mice demonstrate increased fat mass, higher feeding efficiency, and reduced lean body mass. To date only one mutation of MC3R has been identified to be associated with human obesity. Functional analysis of this mutation indicated a complete loss of agonist-mediated receptor activation.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NM_019888.2
Assay Entry
Cell-based beta lactamase reporter gene
Cell State
Dividing Cells
Detection Method
Fluorescent
For Use With (Application)
FRET
Gene Symbol
MC3R
Population Status
Single Cell Clone Origin
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Target Entry
MC3R
Cell Line
CHO-K1
System Type
GeneBLAzer™
Druggable Target
GPCRs

Contents & Storage

Contents:
K1744 GeneBLAzer™ MC3R CRE-bla CHO-K1 DA cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer™ MC3R CRE-bla CHO-K1 cells
• GeneBLAzer™ MC3R CRE-bla CHO-K1 Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer™ MC3R CRE-bla CHO-K1cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

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