The Tango™ CCR4-bla U2OS cells contain the human Chemokine (C-C Motif) Receptor 4 (CCR4) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ CCR4-bla U2OS cells are functionally validated for Z' and EC50 concentrations of TARC. In addition, Tango™ CCR4-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
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