Molecular cloning and characterization of Foxp3 in Atlantic salmon (Salmo salar).
AuthorsZhang Z, Chi H, Niu C, Bøgwald J, Dalmo RA,
JournalFish Shellfish Immunol
PubMed ID21276855
'Foxp3 is a T cell-specific transcription factor and plays a key role in the development of Treg cells and in the immune regulatory process during inflammation. Here we report cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and ... More
Diversity and functionality of arbuscular mycorrhizal fungi in three plant communities in semiarid Grasslands National Park, Canada.
'Septate endophytes proliferating in the roots of grasslands'' plants shed doubts on the importance of arbuscular mycorrhizal (AM) symbioses in dry soils. The functionality and diversity of the AM symbioses formed in four replicates of three adjacent plant communities (agricultural, native, and restored) in Grasslands National Park, Canada were assessed ... More
Detection of cytosine methylation in RNA using bisulfite sequencing.
AuthorsPollex T, Hanna K, Schaefer M
JournalCold Spring Harb Protoc
PubMed ID20889702
'Post-transcriptional RNA modifications are a characteristic feature of noncoding RNAs and have been described for ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), and various other small RNAs. However, the biological function of most of these modifications remains uncharacterized. Cytosine-5 methylation (5mC) has been detected in abundant and long-lived RNA molecules such ... More
Unique DNA methylome profiles in CpG island methylator phenotype colon cancers.
AuthorsXu Y, Hu B, Choi AJ, Gopalan B, Lee BH, Kalady MF, Church JM, Ting AH
JournalGenome Res
PubMed ID21990380
'A subset of colorectal cancers was postulated to have the CpG island methylator phenotype (CIMP), a higher propensity for CpG island DNA methylation. The validity of CIMP, its molecular basis, and its prognostic value remain highly controversial. Using MBD-isolated genome sequencing, we mapped and compared genome-wide DNA methylation profiles of ... More
Evolution of major milk proteins in Mus musculus and Mus spretus mouse species: a genoproteomic analysis.
AuthorsBoumahrou N, Bevilacqua C, Beauvallet C, Miranda G, Andrei S, Rebours E, Panthier JJ, Bellier S, Martin P
JournalBMC Genomics
PubMed ID21276224
'Due to their high level of genotypic and phenotypic variability, Mus spretus strains were introduced in laboratories to investigate the genetic determinism of complex phenotypes including quantitative trait loci. Mus spretus diverged from Mus musculus around 2.5 million years ago and exhibits on average a single nucleotide polymorphism (SNP) in ... More
Enhanced autointegration in hyperstable simian immunodeficiency virus capsid mutants blocked after reverse transcription.
AuthorsTipper C, Sodroski J
JournalJ Virol
PubMed ID23345510
'After entering a host cell, retroviruses such as simian immunodeficiency virus (SIV) uncoat, disassembling the viral capsid. Rates of uncoating that are too high and too low can be detrimental to the efficiency of infection. Rapid uncoating typically leads to blocks in reverse transcription, but the basis for replication defects ... More
Nontarget effects of foliar fungicide application on the rhizosphere: diversity of nifH gene and nodulation in chickpea field.
AuthorsYang C, Hamel C, Vujanovic V, Gan Y
JournalJ Appl Microbiol
PubMed ID22335393
This study explores nontarget effects of fungicide application on field-grown chickpea.
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
AuthorsLiu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, Haverty PM, Gnad F, Guan Y, Gilbert HN, Stinson J, Klijn C, Guillory J, Bhatt D, Vartanian S, Walter K, Chan J, Holcomb T, Dijkgraaf P, Johnson S, Koeman J, Minna JD, Gazdar AF, Stern HM, Hoeflich KP, Wu TD, Settleman J, de Sauvage FJ, Gentleman RC, Neve RM, Stokoe D, Modrusan Z, Seshagiri S, Shames DS, Zhang Z
JournalGenome Res
PubMed ID23033341
Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra ... More