Thermo Scientific™

IDEIA™ Lyme Neuroborreliosis Kit

Catalog number: K602811-2
Thermo Scientific™

IDEIA™ Lyme Neuroborreliosis Kit

Catalog number: K602811-2
Detect the intrathecally produced human IgG and IgM antibodies to Borrelia burgdorferi with Thermo Scientific™ IDEIA™ Lyme Neuroborreliosis Kit. The enzyme immunoassay is designed to deliver rapid detection of human intrathecal IgG and IgM antibodies to Borrelia burgdorferi sensu lato as an aid in the diagnosis of Lyme neuroborreliosis.
 
Catalog Number
K602811-2
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Each
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Full specifications
DescriptionIDEIA™ Lyme Neuroborreliosis Enzyme Immunoassay
Detectable AnalytesB. burgdorferi IgG, IgM
TypeBorrelia Testing Kit
IncludesMicrotitration plate, sample diluent, wash buffer, IgG positive control, IgM negative control, flagellum conjugate, reconstitution buffer, peroxidase complex, substrate TMB, stop solution, instruction booklet
Quantity48 Tests
Unit SizeEach
Showing 1 of 1
Catalog NumberSpecificationsUnit SizePrice (USD)
K602811-2Full specifications
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DescriptionIDEIA™ Lyme Neuroborreliosis Enzyme Immunoassay
Detectable AnalytesB. burgdorferi IgG, IgM
TypeBorrelia Testing Kit
IncludesMicrotitration plate, sample diluent, wash buffer, IgG positive control, IgM negative control, flagellum conjugate, reconstitution buffer, peroxidase complex, substrate TMB, stop solution, instruction booklet
Quantity48 Tests
Unit SizeEach
Showing 1 of 1

Lyme borreliosis is a multisystem infection caused by the tickborne spirochete Borrelia burgdorferi sensu lato. Involvement of the nervous system, neuroborreliosis is a common and serious manifestation of Lyme borreliosis. Neuroborreliosis develops in approximately 10% of patients who have not received treatment for the primary stage lesion. A sensitive and reliable diagnostic test for neuroborreliosis is needed as a number of other diseases with similar symptoms exist and, in contrast to these diseases, neuroborreliosis can be treated with antibiotics.

Use IDEIA Lyme Neuroborreliosis Kit for differential diagnosis of Lyme neuroborreliosis from other potential causes of similar symptoms.

  • Simple—ready-to-use liquid reagents and concentrates make the assay easy to implement and run
  • Excellent sensitivity and specificity—high quality, well characterized antibodies used in the assay provide excellent sensitivity and specificity
  • Easy-to-read results

The assay uses purified, native B. afzelii strain DK1 flagellum as test antigen. The flagellum is highly immunogenic, elicits an early, strong and persistent immune response1,2 , and is the major antigen for the intrathecal antibody response3,4. Compared with the conventional antigen, which is based on whole cell extract of the spirochete, the purified, native flagellar antigen improves the diagnostic sensitivity and specificity of serological assays for Lyme neuroborreliosis5,6. Furthermore, the use of flagellum as test antigen is appropriate in all geographical areas as the flagellum shows no significant variation between B. burgdorferi strains.

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For In Vitro Diagnostic Use.  
  1. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J Clin Invest 78: 934-9.
  2. Karlsson M, Möllegard I, Stiernstedt G, Henriksson M, Wretlind B. (1988) Characterization of antibody response in patients with Borrelia meningitis. Serodiagn Immunother Infect Dis. 2: 375-86.
  3. Wilske B, Schierz G, Preac-Mursic V, von Busch K, Kühbeck R, Pfister, HW, et al. (1986) Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphotic meningoradiculitis (Bannwarth’s syndrome). J Infect Dis. 153: 304-14.
  4. Hansen K, Cruz M, Link H. (1990) Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis. J Infect Dis. 161: 1194-202.
  5. Hansen K, Hindersson P, Pedersen NS. (1988) Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease. J Clin Microbiol 26: 338-46.
  6. Karlsson M. (1990) Western immunoblot and flagellum enzyme-linked immunosorbent assay for serodiagnosis of Lyme borreliosis. J Clin Microbiol 28: 2148-50.

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2°C to 8°C

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