Suppression of tumorigenesis: modulation of inflammatory cytokines by oral administration of microencapsulated probiotic yogurt formulation.
AuthorsUrbanska AM, Paul A, Bhathena J, Bhahena J, Prakash S,
JournalInt J Inflam
PubMed ID21188222
'The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF-a), interferon-gamma (IFN-?), prostaglandin E(2)??(PGE(2)), and thromboxane B2 ... More
A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome.
AuthorsHildebrandt GC, Olkiewicz KM, Corrion L, Clouthier SG, Pierce EM, Liu C, Cooke KR,
JournalBiol Blood Marrow Transplant
PubMed ID18342780
'Idiopathic pneumonia syndrome (IPS) is a frequently fatal complication following allogeneic stem cell transplantation (allo-SCT). Experimental models have revealed that TNF-alpha contributes to pulmonary vascular endothelial cell (EC) apoptosis, and modulates the infiltration of donor leukocytes into the lung parenchyma. The inflammatory effects of TNF-alpha are mediated by signaling through ... More
A label-free differential proteomic analysis of mouse bronchoalveolar lavage fluid exposed to ultrafine carbon black.
AuthorsChiu KH, Lee WL, Chang CC, Chen SC, Chang YC, Ho MN, Hsu JF, Liao PC,
JournalAnal Chim Acta
PubMed ID20599030
Ultrafine carbon black (ufCB) is a potential hazard to the lung. It causes changes in protein expression and it increases alveolar-capillary permeability in the lung. Label-free quantitative proteomic methods allow a sensitive and accurate analytical method for identifying and quantifying proteins in a protein mixture without chemically modifying the proteins. ... More
Effect of flunixin meglumine on cytokine levels in experimental endotoxemia in mice.
AuthorsYazar E, Er A, Uney K, Altunok V, Elmas M,
JournalJ Vet Med A Physiol Pathol Clin Med
PubMed ID17718807
In this study, effect of flunixin meglumine on serum tumour necrosis factor alpha, (TNFalpha) interleukin-1 beta and interleukin-10 levels was investigated in lipopolysaccharide-induced endotoxic mice. Healthy 273 Balb/C mice were used and divided into three equal groups. Group 1 was injected lipopolysaccharide (Escherichia coli 0111:B4, 250 microg/mouse, intraperitoneally), Group 2 ... More
Methyl palmitate inhibits lipopolysaccharide-stimulated phagocytic activity of rat peritoneal macrophages.
AuthorsSarkar S, Khan MF, Kaphalia BS, Ansari GA,
JournalJ Biochem Mol Toxicol
PubMed ID17163484
Macrophages, in general, are critical effectors of body's immune system. Chemical inhibition of phagocytic activity of such macrophages as Kupffer cells has been extensively studied. We have earlier shown that methyl palmitate (MP) inhibits the activation of Kupffer cells. To evaluate the potential of MP to inhibit the activation of ... More
Anti-inflammatory and antifibrotic effects of methyl palmitate.
AuthorsEl-Demerdash E,
JournalToxicol Appl Pharmacol
PubMed ID21575650
Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment of cytotoxicity using MTT assay ... More