Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant.
AuthorsNeujahr DC, Perez SD, Mohammed A, Ulukpo O, Lawrence EC, Fernandez F, Pickens A, Force SD, Song M, Larsen CP, Kirk AD,
JournalAm J Transplant
PubMed ID22151926
'Outcomes following lung transplant are suboptimal owing to chronic allograft failure termed bronchiolitis obliterans syndrome (BOS). Prior work in both mice and humans has shown that interferon gamma (IFNG)-induced chemokines, including CXCL9 and CXCL10, are elevated in patients with established BOS. We hypothesized that patients who ultimately developed BOS would ... More
Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils.
'One of the defining features of the majority of FOXP3(+) Tregs is their inability to produce typical T-cell-derived cytokines. Little is known, however, about their capacity to produce chemokines. As Tregs are constitutively present in, and rapidly traffic to, non-lymphoid tissues, we hypothesized that they may produce chemokines to direct ... More
Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle.
AuthorsLarsson B, Rosendal L, Kristiansen J, Sjøgaard G, Søgaard K, Ghafouri B, Abdiu A, Kjaer M, Gerdle B,
JournalPain
PubMed ID19006649
The trapezius muscle often develops pain as the result of repetitive and stressful work tasks although it is unclear to what extent this pain is due to alterations in muscle concentrations of algesic/nociceptive substances. Twenty women with chronic neck- and shoulder pain (TM) whose work required highly repetitive work tasks ... More
Reciprocal human dendritic cell-natural killer cell interactions induce antitumor activity following tumor cell infection by oncolytic reovirus.
AuthorsPrestwich RJ, Errington F, Steele LP, Ilett EJ, Morgan RS, Harrington KJ, Pandha HS, Selby PJ, Vile RG, Melcher AA,
JournalJ Immunol
PubMed ID19734207
Oncolytic virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated tumor regression. Although the ability of oncolytic viruses to generate adaptive antitumor immunity has been characterized, their interactions with the innate immune system are relatively unclear. Using a human in vitro system, this study investigates the innate immunological consequences ... More
Sterile trauma to normal human dermis invariably induces IL1beta, IL6 and IL8 in an innate response to
AuthorsSjögren F, Anderson C
JournalActa Derm Venereol
PubMed ID19734969
Microdialysis allows the study of the local production and temporal resolution of cytokines in living skin. Samples were taken from the normal skin of 10 healthy subjects for 24-28 h after insertion of a concentric microdialysis catheter, and analysed with a Luminex bead-based assay. Interleukin-1 beta (IL1b), IL6 and IL8 ... More
Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone.
AuthorsCoutanceau E, Decalf J, Martino A, Babon A, Winter N, Cole ST, Albert ML, Demangel C
JournalJ Exp Med
PubMed ID17517970
Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). Surprisingly, infected tissues lack inflammatory infiltrates. Structural similarities between mycolactone and immunosuppressive agents led us to investigate the immunomodulatory properties of mycolactone on dendritic cells (DCs), the key initiators and ... More
Characterization of myeloid and plasmacytoid dendritic cells in human lung.
AuthorsMasten BJ, Olson GK, Tarleton CA, Rund C, Schuyler M, Mehran R, Archibeque T, Lipscomb MF
JournalJ Immunol
PubMed ID17114449
Dendritic cells (DCs) are bone marrow-derived mononuclear cells that play a central role in the initiation of immune responses. Because human lung DCs have been incompletely characterized, we enumerated and phenotyped mononuclear cell populations from excess lung tissue obtained at surgery. Myeloid DCs (MDCs) were identified as CD1c(+)CD11c(+)CD14(-)HLA-DR(+) cells and ... More
Differential monocyte responses to TLR ligands in children with autism spectrum disorders.
AuthorsEnstrom AM, Onore CE, Van de Water JA, Ashwood P
JournalBrain Behav Immun
PubMed ID19666104
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. Recent evidence has suggested that impairments of innate immunity may play an important role in ASD. To test this hypothesis, we isolated peripheral blood monocytes from 17 children with ASD and ... More
Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders.
AuthorsAshwood P, Schauer J, Pessah IN, Van de Water J
JournalJ Neuroimmunol
PubMed ID19211157
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders that manifest in childhood. Immune dysregulation and autoimmune reactivity may contribute to the etiology of ASD and are likely the result of both genetic and environmental susceptibilities. A common environmental contaminant, 2,2',4,4'-tetrabrominated biphenyl (BDE-47), was tested for differential effects on the immune ... More