Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.
AuthorsShao X, Yang R, Yan M, Li Y, Du Y, Raman I, Zhang B, Wakeland EK, Wakeland W, Igarashi P, Mohan C, Li QZ,
JournalArthritis Rheum
PubMed ID23280471
'To ascertain whether engineered expression of kallikreins within the kidneys, using an inducible Cre/loxP system, can ameliorate murine lupus nephritis. In mice with a lupus-prone genetic background, we engineered the expression of tamoxifen-inducible Cre recombinase under the control of a kidney-specific promoter whose activation initiates murine kallikrein-1 expression within the ... More
Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice.
'Since statins and fibrates are capable of improving the metabolic profile of patients as well as decreasing inflammation, they are considered as potential drugs for preventing osteoarthritis (OA). The goal of the present study was to investigate the effect of these drugs in the STR/Ort spontaneous OA mouse model. Male ... More
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.
AuthorsRaimondi G, Sumpter TL, Matta BM, Pillai M, Corbitt N, Vodovotz Y, Wang Z, Thomson AW,
JournalJ Immunol
PubMed ID20007530
'Minimization of immunosuppression and donor-specific tolerance to MHC-mismatched organ grafts are important clinical goals. The therapeutic potential of regulatory T cells (Tregs) has been demonstrated, but conditions for optimizing their in vivo function posttransplant in nonlymphocyte-depleted hosts remain undefined. In this study, we address mechanisms through which inhibition of the ... More
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-?B and MAPK signaling.
AuthorsPhilip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE,
Journal
PubMed ID24799700
'Toll-like receptor signaling and subsequent activation of NF-?B- and MAPK-dependent genes during infection play an important role in antimicrobial host defense. The YopJ protein of pathogenic Yersinia species inhibits NF-?B and MAPK signaling, resulting in blockade of NF-?B-dependent cytokine production and target cell death. Nevertheless, Yersinia infection induces inflammatory responses ... More
GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state.
AuthorsSharma G, Hu C, Brigman JL, Zhu G, Hathaway HJ, Prossnitz ER,
Journal
PubMed ID23970785
'Estrogen is an important regulator of metabolic syndrome, a collection of abnormalities including obesity, insulin resistance/glucose intolerance, hypertension, dyslipidemia, and inflammation, which together lead to increased risk of cardiovascular disease and diabetes. The role of the G protein-coupled estrogen receptor (GPER/GPR30), particularly in males, in these pathologies remains unclear. We ... More
Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.
AuthorsLi Y, Raman I, Du Y, Yan M, Min S, Yang J, Fang X, Li W, Lu J, Zhou XJ, Mohan C, Li QZ,
Journal
PubMed ID23935844
Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human ... More
Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery.
AuthorsPredina J, Eruslanov E, Judy B, Kapoor V, Cheng G, Wang LC, Sun J, Moon EK, Fridlender ZG, Albelda S, Singhal S,
JournalProc Natl Acad Sci U S A
PubMed ID23271806
Each year, more than 700,000 people undergo cancer surgery in the United States. However, more than 40% of those patients develop recurrences and have a poor outcome. Traditionally, the medical community has assumed that recurrent tumors arise from selected tumor clones that are refractory to therapy. However, we found that ... More
Amyloid-ß concentration and structure influences the transport and immunomodulatory effects of IVIG.
AuthorsWuest DM, Lee KH,
Journal
PubMed ID24517534
Intravenous immunoglobulin (IVIG) contains anti-amyloid-ß antibodies as well as antibodies providing immunomodulatory effects that may modify chronic inflammation in Alzheimer's disease. Answers to important questions about IVIG transport into the central nervous system and assessments of any impact amyloid-ß has on this transport can be provided by in vitro models ... More