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Invitrogen
ZPR1 Recombinant Rabbit Monoclonal Antibody (10V1A2)
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FIGURE: 1 / 2
ZPR1 Antibody (MA5-42670) in IHC (P)
Immunohistochemistry analysis of ZPR1 in paraffin-embedded human liver cancer. Samples were incubated with ZPR1 Monoclonal antibody (Product # MA5-42670) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-42670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10V1A2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 360-459 of human ZNF259 (O75312).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.38 mg/mL
Amount
38 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse brain. The target is usually found in the following locations: Cajal body, Cell projection, Cytoplasm, Nucleus, axon, gem, growth cone, nucleolus, perinuclear region.
Immunogen sequence: DIRELVTKNP FTLGDSSNPG QTERLQEFSQ KMDQIIEGNM KAHFIMDDPA GNSYLQNVYA PEDDPEMKVE RYKRTFDQNE ELGLNDMKTE GYEAGLAPQR
Target Information
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: unnamed protein product; Zinc finger protein 259; Zinc finger protein ZPR1
Gene Aliases: AI303781; GKAF; Zfp259; ZNF259; ZPR1
UniProt ID: (Human) O75312, (Mouse) Q62384
Entrez Gene ID: (Human) 8882, (Mouse) 22687
microtubule cytoskeleton organization
inner cell mass cell proliferation
trophectodermal cell proliferation
mRNA processing
multicellular organism development
RNA splicing
positive regulation of gene expression
spinal cord development
cell differentiation
Cajal body organization
regulation of myelination
positive regulation of RNA splicing
DNA endoreduplication
positive regulation of protein import into nucleus
positive regulation of growth
axon development
cellular response to epidermal growth factor stimulus
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
apoptotic process involved in development
pre-mRNA catabolic process
negative regulation of motor neuron apoptotic process
DNA replication
protein folding
signal transduction
positive regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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