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Invitrogen
MDA5 Recombinant Rabbit Monoclonal Antibody (23GB6270)
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FIGURE: 1 / 2
MDA5 Antibody (MA5-53010) in ICC/IF
Immunocytochemistry analysis of MDA5 in HepG2 cells. Sample was incubated with MDA5 monoclonal (Product # MA5-53010) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-53010
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB6270
Immunogen
A synthesized peptide derived from human MDA5 (950-1025AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CADM-140 autoantigen; clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; helicard; helicase; helicase with 2 CARD domains; interferon induced with helicase C domain protein 1; melanoma differentiation-associated gene 5; melanoma differentiation-associated protein 5; MGC133047; murabutide down-regulated protein; RIG-I-like receptor 2; RNA helicase; RNA helicase-DEAD box protein 116; RNA helicase; MDA-5; RNA-dependent ATPase; unnamed protein product
Gene Aliases: 9130009C22Rik; AGS7; Helicard; Hlcd; IDDM19; IMD95; MDA-5; MDA5; RGD1560496; RLR-2; SGMRT1
UniProt ID: (Human) Q9BYX4, (Mouse) Q8R5F7
Entrez Gene ID: (Human) 64135, (Mouse) 71586, (Rat) 499801
DNA binding
RNA binding
RNA helicase activity
double-stranded RNA binding
single-stranded RNA binding
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
protein domain specific binding
pattern recognition receptor activity
identical protein binding
ribonucleoprotein complex binding
cytoplasmic pattern recognition receptor signaling pathway
signal transduction
detection of virus
response to virus
protein sumoylation
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of type III interferon production
MDA-5 signaling pathway
negative regulation of viral genome replication
innate immune response
protein oligomerization
defense response to virus
positive regulation of response to cytokine stimulus
cellular response to exogenous dsRNA
cellular response to virus
antiviral innate immune response
mRNA transcription
type I interferon signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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