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Invitrogen
DKC1 Recombinant Rabbit Monoclonal Antibody (23GB1810)
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FIGURE: 1 / 3
DKC1 Antibody (MA5-53108) in ICC/IF
Immunocytochemistry analysis of DKC1 in HepG2 cells. Nuclei were stained blue with DAPI; DKC1 recombinant monoclonal antibody (Product # MA5-53108) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-53108
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB1810
Immunogen
A synthesized peptide derived from human DKC1 (350-400AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.42 mg/mL
Amount
42 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBF5 homolog; dyskeratosis congenita 1, dyskerin; dyskeratosis congenita 1, dyskerin homolog; dyskerin; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit 4 isoform 3; nopp140-associated protein of 57 kDa; nucleolar protein; nucleolar protein family A member 4; nucleolar protein NAP57; snoRNP protein DKC1; unnamed protein product
Gene Aliases: CBF5; CHINE1; DKC; Dkc1x; Dkc1y; DKCX; NAP57; NOLA4; XAP101
UniProt ID: (Human) O60832, (Rat) P40615, (Mouse) Q9ESX5
Entrez Gene ID: (Human) 1736, (Rat) 170944, (Mouse) 245474
snoRNA guided rRNA pseudouridine synthesis
enzyme-directed rRNA pseudouridine synthesis
box H/ACA snoRNA 3'-end processing
pseudouridine synthesis
RNA processing
telomere maintenance via telomerase
positive regulation of cell proliferation
RNA modification
rRNA pseudouridine synthesis
snRNA pseudouridine synthesis
positive regulation of telomere maintenance via telomerase
box H/ACA snoRNA metabolic process
scaRNA localization to Cajal body
telomerase RNA stabilization
regulation of telomerase RNA localization to Cajal body
positive regulation of telomerase RNA localization to Cajal body
telomerase holoenzyme complex assembly
mRNA pseudouridine synthesis
rRNA processing
protein localization to Cajal body
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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