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Invitrogen

Calcineurin A Recombinant Rabbit Monoclonal Antibody (23GB2855)

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Calcineurin A Recombinant Rabbit Monoclonal Antibody (23GB2855)

Product Details

MA5-53278

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB2855

Immunogen

A synthesized peptide derived from human Calcineurin A (470-521AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Amount

80 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3247751

Target Information

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calcineurin; calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; CalcineurinA; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase 3 catalytic subunit alpha isozyme; unnamed protein product

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Gene Aliases: 2900074D19Rik; ACCIID; CALN; CALNA; CALNA1; CN; CnA; CNA1; DEE91; IECEE; IECEE1; PPP2B

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UniProt ID: (Human) Q08209, (Mouse) P63328

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Entrez Gene ID: (Human) 5530, (Mouse) 19055

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Function(s)
protein serine/threonine phosphatase activity calcium ion binding protein binding calmodulin binding hydrolase activity enzyme binding calmodulin-dependent protein phosphatase activity protein dimerization activity ATPase binding phosphoprotein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity macromolecular complex binding
Process(es)
G1/S transition of mitotic cell cycle protein dephosphorylation protein import into nucleus calcium ion transport epidermis development positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression transition between fast and slow fiber cardiac muscle hypertrophy in response to stress dephosphorylation calcium-mediated signaling negative regulation of signaling keratinocyte differentiation positive regulation of cell migration calcineurin-NFAT signaling cascade multicellular organismal response to stress positive regulation of activated T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion positive regulation of saliva secretion skeletal muscle fiber development negative regulation of dendrite morphogenesis modulation of synaptic transmission response to calcium ion excitatory postsynaptic potential regulation of cell proliferation involved in kidney morphogenesis peptidyl-serine dephosphorylation renal sodium ion absorption positive regulation of calcineurin-NFAT signaling cascade cellular response to glucose stimulus positive regulation of glomerulus development renal filtration calcineurin-mediated signaling postsynaptic modulation of chemical synaptic transmission negative regulation of angiotensin-activated signaling pathway positive regulation of angiotensin-activated signaling pathway positive regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of cardiac muscle hypertrophy in response to stress positive regulation of connective tissue replacement positive regulation of calcium ion import across plasma membrane negative regulation of calcium ion import across plasma membrane wound healing T cell activation skeletal muscle tissue regeneration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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