A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.
AuthorsReinherz EL, Kung PC, Goldstein G, Schlossman SF
JournalJ Immunol
PubMed ID157372
Stimulation of CD5 enhances signal transduction by the T cell antigen receptor.
AuthorsImboden JB, June CH, McCutcheon MA, Ledbetter JA
JournalJ Clin Invest
PubMed ID1688565
After the addition of a CD3 monoclonal antibody to peripheral T cells that have been previously stimulated with phytohemagglutinin, inositol phosphates are produced at a rapid rate for 2 min and at a much slower rate thereafter. Stimulation of CD5 allows CD3-mediated production of inositol phosphates to be sustained at ... More
Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1.
The T1/Leu-1/CD5 molecule, a human T-cell surface glycoprotein of relative molecular mass (Mr) 67,000, has been implicated in the proliferative response of activated T cells and in T-cell helper function. A similar involvement in T-cell proliferation has been reported for Ly-1, the murine homologue of T1. Here we report the ... More
Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase-bound OKT3.
AuthorsCeuppens JL, Baroja ML
JournalJ Immunol
PubMed ID3091691
Activation of human peripheral blood T cells by the anti-CD3 antibody OKT3 has been shown to require not only cross-linking of CD3 molecules with multimeric binding of the Fc part of OKT3 to a solid support, but also a second accessory cell-provided signal. Accordingly, measurement of T cell activation in ... More