Thermo Scientific™

Lab Vision™ MMP-11 (Stromelysin-3) Ab-5, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-11 (Stromelysin-3) Ab-5, Mouse Monoclonal Antibody.
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Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The stromelysin-3 (MMP-11) gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is localized by in situ hybridization to the long arm of chromosome 22. The MMP-11 expression is found more specifically in malignant tumors than in benign ones.

Host Species: Mouse

Clone: SL3.05

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Immunogen: Recombinant protein corresponding to active form of human MMP-11

Molecular Weight: ∽60kDa (latent), ∽47kDa (active) and ∽35kDa (degradation product)

Positive Control: Recombinant MMP-11 protein; Placenta

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)
  • Affinity Purification (Not verified)

Note:

USA: RUO; Int'l: RUO

General References:

1. Asch PH, et al. Am J Dermatopathol 1999 Apr21(2):146-50..

2. Basset P, et al. Nature 1990 Dec 20-27348(6303):699-704.