Thermo Scientific™

Lab Vision™ PCNA (Proliferating Cell Nuclear Antigen) Ab-1, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Provides accurate, reproducible results with the Thermo Scientific™ PCNA (Proliferating Cell Nuclear Antigen) Ab-1, Mouse Monoclonal Antibody.
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Expression of proliferating cell nuclear antigen (PCNA) or cyclin or polymerase δ auxiliary protein is elevated in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. Its level correlates directly with rates of cellular proliferation and DNA synthesis. PCNA/cyclin may act as an auxiliary protein of DNA polymerase-δ to play a fundamental role in the initiation of cell proliferation

Host Species: Mouse

Clone: PC10

Isotype: IgG2a/κ

Species Reactivity: Human, Mouse, Rat, Insect, and Yeast. Others not known.

Epitope: Not determined

Immunogen: Recombinant rat PCNA protein

Molecular Weight: 36kDa

Positive Control: Raji cells; Tonsil, lymph node, or small intestine

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native and denatured)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

General References:

1. Waseem N and Lane D. (1990) J Cell Sci 96:121-129

2. Hall P A, et al. (1990) J Path 162:285-294.

3. Jain S, et al(1991) J Clin Pathol 44:655-659.

4. Woods A L, et al. (1991) Histopathol 19:21-27.

5. Yu C C, et al (1991) Histopathol 19:29-33.