Thermo Scientific™

Lab Vision™ p57 Kip2 Ab-6, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-6, Mouse Monoclonal Antibody.
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p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Mouse

Clone: 57P06; same as KP10

Isotype: IgG2b/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: Not determined

Immunogen: Recombinant human p57Kip2 protein

Molecular Weight: 57kDa

Positive Control: LS174T cells, Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)
  • Immunoprecipitation (Native verified)

General References:

1. Overall ML, et al. Genes Chromosomes Cancer 1996 17(1):56-59.

2. Hatada I, et al. Hum Mol Genet 1996 Jun5(6):783-788.