Host Species: Mouse
Clone: 1F8; same as Rb1
Species Reactivity: Human. Does not react with mouse and rat. Others not known.
Epitope: aa 703-722
Immunogen: Recombinant human Rb protein
Molecular Weight: 105kDa
Positive Control: Ls174T, HT29, HUVEC cells; Normal colon, Breast CA and colon CA
Cellular Localization: Nuclear Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein. It shows no cross reaction with p107 and p130.
USA: RUO; Int'l: RUO
1. Bartek J, et. al. Oncogene 7:101-108, 1992.
2. Grand R et. al. Oncogene. 4:1291-1298, 1989.