Cytochrome c Ab-2, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Specifically detect Cytochrome c in human, mouse, rat, horse, dog, pigeon, frog and Drosophila samples with Thermo Scientific™ Cytochrome c Ab-2, Mouse Monoclonal Antibody, which provides accurate, reproducible results.

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Cytochrome c is an electron transporting protein that resides within the inter-membrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome c has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome c is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome c functions in the activation of caspase-3, and ICE family molecule that is a key effector of apoptosis.

Host Species: Mouse

Clone: 7H8.2C12

Isotype: IgG2b/κ

Species Reactivity: Human, Mouse, Rat, Horse, Dog, Pigeon, Frog and Drosophila. Others not known.

Epitope: Not determined

Immunogen: Synthetic peptides corresponding to amino acids 1-80, 81-104 and 66-104 of pigeon cytochrome c

Molecular Weight: 15 kDa

Positive Control: HeLa cells

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Not suitable)


USA: RUO; Int'l: RUO

General References:

1. Liu X, et al. (1996) Cell 86: 147-157.

2. Jemmerson, R., et al. (1991) Eur. J. Immunol. 21: 143-151.


Manuals & protocols