Thermo Scientific™

Lab Vision™ Mast Cell Tryptase Ab-2, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mast Cell Tryptase Ab-2, Mouse Monoclonal Antibody.

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Description

Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is estimated to be found in mast cells of skin and lung and suggestes this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Human mast cell tryptase has considerable potential as a marker for mast cell activation as well as being a mediator of inflammation.

Host Species: Mouse

Clone: AA1

Isotype: IgG1

Species Reactivity: Human, Monkey, Dog and Cat. Others not known.

Epitope: Not determined

Immunogen: Human mast cell tryptase purified from human lung tissues

Positive Control: Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO

General References:

1. Goldsmith P, et al. (1990) Digestive Diseases and Sciences. 35: 1409-1413.

2. Walls A F, et al. (1990) J Pathol. 162: 119-126.

3. Walls A F, et al. (1990) Clin Exp Allergy, 20:581-590.



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