Thermo Scientific™

Lab Vision™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence and immunoprecipitation experiments with Thermo Scientific™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody.
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CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Host Species: Mouse

Clone: M3A7

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: aa 1370-1380

Immunogen: Recombinant protein encoding NBF2 domain of human CFTR

Molecular Weight: 165-170 kDa

Positive Control: Pancreas

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

General References:

1. Kartner N. et al. Nature Genetics 1:390, 321-327. 1992.

2. Gergely L et al. J Biol. Chem. 268:29, 21592-21598, 1993.