CD15 Ab-3, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Ensure accurate, reproducible results in immunohistochemistry and flow cytometry procedures with Thermo Scientific™ CD15 Ab-3, Mouse Monoclonal Antibody.

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Description

3-fucosyl-N-acetyllactosamine (3-FAL) or CD15 or X-hapten plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is also expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin's disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.

Host Species: Mouse

Clone: MMA; same as LeuM1

Isotype: IgM/κ

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: U937 histiocytic cell line

Molecular Weight: 220kDa

Positive Control: Reed-Sternberg's cells in Hodgkin's lymphoma

Cellular Localization: Membrane and granular paranuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Flow Cytometry

General References:

1. Hanjan SNS, et al . Clin Immuno Immunopath. 1982 23: 172.

2. Skubitz K, et al In: Knapp W, Dorken B, Gilks WR, et al, eds. Leucocyte Typing IV: White Cell Differentiation Antigens. New York: Oxford University Press 1989 800-805.

3. Hsu SM, et al. Amer J Clin Path. 1984 82:29.

4. Pinkus GS, et al. Am J Pathol. 1985 119:244.



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