Thermo Scientific™

Lab Vision™ Involucrin Ab-1, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology

Thermo Scientific™ Involucrin Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results. 

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Description

Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

Host Species: Mouse

Clone: SY5

Isotype: IgG1

Species Reactivity: Human, Gorilla, Owl, Monkey, Pig, Dog and Rat. Others not known.

Epitope: Codon 421-568

Immunogen: Human keratinocytes' involucrin

Molecular Weight: 66-170kDa

Positive Control: LS174T cells, Skin

Cellular Localization: Cytoplasmic Ab-1 stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ∽115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Denatured verified)
  • ELISA

Note:

USA: RUO; Int'l: RUO

General References:

1. Hudson DL, et. al. Hybridoma, 1992, 11:367.



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