MHC II (HLA-DR) Ab-1, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Ensure accurate, reproducible results in immunohistochemistry and flow cytometry experiments with the Thermo Scientific™ MHC II (HLA-DR) Ab-1, Mouse Monoclonal Antibody.

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Description

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an α chain (36 kDa) and a β chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.

Host Species: Mouse

Clone: LN3

Isotype: IgG2b

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Activated human peripheral blood mononuclear cells

Molecular Weight: 36kDa (α-chain) and 27kDa (β-chain)

Positive Control: Tonsil/lymph node

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

General References:

1. Ioachim HL et al. Int J Cancer. Supplement, 1994, 8:132-3.

2. Vonderheid EC et al. Cancer, 1994, 73(1):207-18.



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