Laminin B2/γ 1 Ab-2, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Recommended for Immunohistochemistry (Formalin/paraffin), Western Blotting (Not verified) and Immunoprecipitation (Not verified), Thermo Scientific™ Laminin B2/γ1 Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.

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Description

Laminins are large heterotrimeric, noncollagenous glycoproteins composed of α, β, and γ chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.

Host Species: Mouse

Clone: D18

Isotype: IgG2a/κ

Species Reactivity: Human, Rat and Guinea Pig. Others not known.

Epitope: Not determined

Immunogen: Rat glomerular basement membrane

Molecular Weight: ∽210kDa

Positive Control: LS174T cells, Skin

Cellular Localization: Basement membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO

General References:

1. Green, T.L. et al. J. Biol. Chem. (1992) 267, 2014-2022.

2. Sanes, J.R. et al. J. Cell Biol. (1990) 111, 1685-1699.



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