Thermo Scientific™

Lab Vision™ TAG-72/CA 72-4™ Ab-1, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Provide accurate, reproducible results with the Thermo Scientific™ TAG-72/CA 72-4 Ab-1, Mouse Monoclonal Antibody.

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Description

Tumor-associated glycoprotein (TAG-72) is an oncofetal antigen with properties of a mucin. About 60% of carcinoma patients express TAG-72 in their sera.

Host Species: Mouse

Clone: B72.3

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Dog, Hamster and Rat. Others not known.

Epitope: Mucin-carried-sialylated-Tn epitope

Immunogen: Membrane-enriched fraction of a human breast carcinoma liver metastasis

Molecular Weight: >1000kDa

Positive Control: Breast or lung CA

Cellular Localization: Cell surface and cytoplasmic. The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for Ab-1 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium. Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3-).

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Flow Cytometry
  • Radioimaging

Note:

USA: RUO; Int'l: RUO

General References:

1. Brown RW et al. Human Pathol, 1993, 24:347-54.

2. Myers RB et al. J Urol, 1994, 152(1):243-6.

3. Roa RA et al. Laryngoscope, 1994, 104:304-8.



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