Villin Ab-1, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Employ one marker in a comprehensive antibody portfolio that addresses all major disease states with the Thermo Scientific™ Villin Ab-1, Mouse Monoclonal Antibody.

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Description

Villin can cap, nucleate, sever and bundle actin in a Ca and phosphoinositide-regulated manner. It is associated with the microvillar actin core bundle of intestinal and renal brush border implicated in adsorption. Villin is composed of six repeats, each containing 150 residues that together constitute the core domain followed by the carboxyl-terminal headpiece domain of 87 residues. The core domain retains the Ca dependent capping nucleating and severing activity, whereas the headpiece domain contributes towards actin filament bundling and binding F-actin, independently of Ca

Host Species: Mouse

Clone: CWWB1

Isotype: IgG1

Species Reactivity: Human. Others not known.

Immunogen: Human Villin protein

Molecular Weight: 92.5kDa

Positive Control: Small intestine and kidney

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)


General References:

1. Fath K R, Burgess D R. (19950 Curr. Biol. 5: 591-593.

2. Friederich E, et al. J. Biol. Chem. 274: 26751-26760.



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