Thermo Scientific™

Lab Vision™ PTEN/MMAC1 Ab-4, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Provide accurate, reproducible results with the Thermo Scientific™ PTEN/MMAC1 Ab-4, Mouse Monoclonal Antibody.
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PTEN/MMAC1, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling.

Host Species: Mouse

Clone: 17.A

Isotype: IgM/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human PTEN protein

Molecular Weight: 60kDa

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry

Note:

USA: RUO; Int'l: RUO

General References:

1. Torres J, et al. (2001) Heterogeneous loss of the tumor suppressor PTEN protein in human neoplastic tissues. Eur. J. Cancer 37: 114-121.