Thermo Scientific™

Lab Vision™ HER-3/c-erbB-3 Ab-2, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Recommended for Western Blotting and Immunoprecipitation (Native and denatured), Thermo Scientific™ HER-3/c-erbB-3 Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.
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c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.

Host Species: Mouse

Clone: 2F12

Isotype: IgG2a/κ

Species Reactivity: Human, Cow, Rat and Mouse. Others not tested.

Epitope: aa 1295-1323

Immunogen: Recombinant rat HER-3/c-erbB-3 oncoprotein

Molecular Weight: 185kDa

Positive Control: T47D cells

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

General References:

1. Prigent SA and Lemoine NR. Progress in Growth Factor Research, 1992, 4: 1-24.

2. Plowman GD, et al. Proc Natl Acad Sci USA, 1993, 90: 1746-50.

3. Krauss MH, et al. Proc Natl Acad Sci USA, 1989, 86: 9193-7.