Thermo Scientific™

Lab Vision™ HER-3/c-erbB-3 Ab-4, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Provide accurate, reproducible results with the Thermo Scientific™ HER-3/c-erbB-3 Ab-4, Mouse Monoclonal Antibody.

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Description

c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.

Host Species: Mouse

Clone: H3.90.6; same as Ab90

Isotype: IgG2a

Species Reactivity: Human. Others not tested.

Epitope: Extracellular domain

Immunogen: Extracellular fragment of recombinant human HER-3/c-erbB-3 oncoprotein

Molecular Weight: 185kDa

Positive Control: T47D cells

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Effect on Heregulin (NDF) Binding (Noninhibitory)
  • Effect on Tumor Growth (Noninhibitory)

Note:

USA: RUO; Int'l: RUO

General References:

1. Chen X et. al. Journal of Biological Chemistry, 1996, 271(13):7620-9.



Documents

Manuals & protocols