Thermo Scientific™

Lab Vision™ Vascular Endothelial Growth Factor (VEGF) Ab-3, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Provide accurate, reproducible results with the Thermo Scientific™ Vascular Endothelial Growth Factor (VEGF) Ab-3, Mouse Monoclonal Antibody.

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Description

VEGF (vascular endothelial growth factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability inducing properties specific for the vascular endothelium. Of the four isoforms of VEGF, the smaller two, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two (VEGF189 and VEGF206) remain cell associated.

Host Species: Mouse

Clone: JH121

Isotype: IgG1/κ

Species Reactivity: Human and Rabbit. Others not known.

Epitope: Not determined

Immunogen: Recombinant human VEGF121

Molecular Weight: 19-22kDa (reduced)

Positive Control: VEGF165 recombinant protein, Angiosarcoma

Cellular Localization: Cytoplasmic, cell surface and extracellular matrix Ab-3 is excellent for neutralizing the bioactivity of human VEGF.

Recommended for:

  • Neutralizes Bioactivity of VEGF

Note:

USA: RUO; Int'l: RUO

General References:

1. Brown LF et al. Human Pathology, 1995 Jan, 26(1):86-91.

2. Boocock CA et al. Journal of the National Cancer Institute, 1995 Apr 5, 87(7):506-16.



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