Thermo Scientific™

Lab Vision™ DNA-PKcs Ab-1, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Inhibit DNA-dependent phosphorylation and perform other studies with Thermo Scientific™ DNA-PKcs Ab-1, Mouse Monoclonal Antibody, which provides accurate, reproducible results.
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DNA-dependent Protein Kinase (DNA-PKcs) phosphorylates transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. In vivo, it is involved in repairing double strand DNA breaks.

Host Species: Mouse

Clone: 18-2

Isotype: IgG1

Species Reactivity: Human and Rat. Others not known.

Epitope: aa 1-2713

Immunogen: Human DNA-dependent Protein Kinase purified from HeLa cells

Molecular Weight: 460 kDa

Positive Control: LS174T cells, Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Inhibits (50%) DNA-dependent Phosphorylation

Note:

USA: RUO; Int'l: RUO

General References:

1. Konno-Sato S et al. Biochem Mol Biol Intl, 1993 31:113-24.

2. Kirchgessner CU et al. Science, 1995, 267(5201):1178-83.

3. Carter T et al. Mol Cell Biol, 1990, 10:6460-71.

4. Han Z et al. J Biol Chem, 1996 271:25035-40.

5. Poltoratsky VP et al. J Immunol, 1995, 155(10):4529-33.