Thermo Scientific™

Lab Vision™ Interferon-α (II)/IFN-α (II), Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Recommended for blocking studies, Thermo Scientific™ Interferon-α (II)/IFN-α (II), Mouse Monoclonal Antibody provides accurate, reproducible results.

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Description

The IFN-α family consists of 24 or more genes or pseudo-genes. IFN-αII) is one of the two distinct families (I and II) of human IFN-α. The α interferons are mainly produced by lymphocytes, monocytes, macrophages, and cell lines such as Namalwa and KG1 following induction by viruses, nucleic acids, and glucocorticoid hormones. They are involved in virus resistance on target cells, inhibition of cell proliferation, induction of cytokines and regulation of expression of MHC class I antigens.

Host Species: Mouse

Clone: N27

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: aa 43-53

Immunogen: Purified recombinant IFN-α 2c

Molecular Weight: 16-27kDa

Positive Control: Stimulated human peripheral blood mononuclear cells

Recommended for:

  • Blocking study

Note:

USA: RUO; Int'l: RUO

General References:

1. Kontsek P et al. Immunol Lett 1993, 35(3):281-284

2. Kontsek P et al. Mol Immunol 1991, 28:1289-1297

3. Pestka S et al. Annu Rev Biochem 1987, 56:727-777

4. Capon DJ et al. Mol Cell Biol 1985, 5(4):768-779

5. Kurane I et al. J Exp Med 1987, 166(4):999-1010

6. Lepe-Zuniga JL et al. J Interferon Res 1989, 9:445-456

7. Aman MJ et al. Blood 1996, 87(11):4731-4736

8. Sen GC et al. J Biol Chem 1992, 267(8):5017-5020



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