Host Species: Mouse
Species Reactivity: Human, Cow, Pig, Rat, Mouse, Guinea Pig, Gerbil, Frog and Chicken. Others not known.
Epitope: aa 426-450
Immunogen: Native chick brain microtubules
Molecular Weight: 57kDa
Positive Control: Ls174T, MAD109 cells; skin or lung
Cellular Localization: Cytoplasmic Ab-2 causes the 10nm filaments to collapse into large lateral aggregates collecting in the cell periphery or tight juxtanuclear caps. It does not block microtubule assembly. It does not inhibit polymerization or depolymerization of platelet tubulin in vitro. It blocks (by 70-80%) the ability of tubulin dimers (with GppNHp bound) to promote a stable inhibition of adenylyl cyclase.
USA: RUO; Int'l: RUO
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