MART-1/Melan-A (Melanoma Marker) Ab-1, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MART-1/Melan-A (Melanoma Marker) Ab-1, Mouse Monoclonal Antibody.

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Description

MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-Ais a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum.

Host Species: Mouse

Clone: M2-7C10

Isotype: IgG2b/κ

Species Reactivity: Human and Horse. Does not react with mouse and rat. Others not tested.

Epitope: Not determined

Immunogen: Recombinant hMART-1 protein

Molecular Weight: 18kDa

Positive Control: CAC1 melanoma cells and melanomas

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Denatured verified)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

General References:

1. Marincola FM, et. al. Journal of Immunotherapy with Emphasis on Tumor Immunology, 1996, 19(3):192-205.

2. Kawakami Y, et. al. Journal of Immunological Methods, 1997, 202(1):13-25.



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