Thermo Scientific™

Lab Vision™ Insulin Receptor (α -Subunit) Ab-2, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Ensure accurate, reproducible results in experiments with Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-2, Mouse Monoclonal Antibody.

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Description

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain, whereas the α-subunit (135kDa) is completely extracellular.

Host Species: Mouse

Clone: 83-7

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Pig, Sheep and Rabbit. Does not react with mouse and rat.

Epitope: Exon 3

Immunogen: IM-9 lymphocytes followed by IR

Molecular Weight: 135kDa

Positive Control: IM-9 lymphocyte cells, Placenta

Cellular Localization: Cell membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • ELISA
  • Flow Cytometry
  • Insulin-like Agonist
  • Does Not Significantly Inhibit Insulin Binding
  • Tyrosine Kinase Assay (Ab-mediated capture on microplates)

Note:

USA: RUO; Int'l: RUO

General References:

1. Soos MA, et. al. Biochem J, 1989, 263(2):553-63.

2. Soos MA, et. al. Biochem J, 1986, 235(1):199-208.

3. Soos MA, et. al. Proc Natl Acad Sci USA, 1989, 86(14):5217-21.

4. Macaulay SL, et. al. Biochem J, 1995, 306:811-20.

5. Zhang B, et. al. Proc Natl Acad Sci USA, 1991, 88:9858-62.

6. Prigent SA, et. al. J Bio Chem, 1990, 265:9970-7.

7. Taylor R, et. al. Biochem J, 1987, 242(1):123-9.



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