Thermo Scientific™

Lab Vision™ Insulin Receptor (β -Subunit) Ab-5, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Recommended for a variety of molecular biology techniques, Thermo Scientific™ Insulin Receptor (β-Subunit) Ab-5, Mouse Monoclonal Antibody provides accurate, reproducible results.

Error loading your content!

  Catalog number Price ({{currency}}) Availability Qty
{{product.sku}}
also known as {{product.formattedSku}} 
{{product.availability.message}} Add To Cart

{{addItemToList.successMessage}} {{addItemToList.listName}}


Back to top

Description

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain with tyrosine kinase acivity, whereas the α-subunit (135kDa) is completely extracellular.

Host Species: Mouse

Clone: CT-1

Isotype: IgG1/κ

Species Reactivity: Human, Mouse and Rat.

Epitope: aa-GRVLTLPRS- within the C-terminus

Immunogen: A 15-mer synthetic peptide corresponding to aa Tyr-KKNGRILTLPRSNPS from the C-terminal of human insulin receptor β-subunit

Molecular Weight: 95kDa

Positive Control: IM-9 lymphocyte cells

Cellular Localization: Membrane Ab-5 reacts with autophosphorylated and unoccupied receptors as well as the receptor-insulin complex. Ab-5 does not affect insulin-stimulated autophosphorylation.

Recommended for:

  • Immunoprecipitation
  • Affinity Purification (With peptide elution)
  • ELISA (As capture antibody only)
  • Tyrosine Kinase Assay (Ab-mediated capture on microplates)

Note:

USA: RUO; Int'l: RUO

General References:

1. Ganderton RH, et. al. Biochem J, 1992, 288:195-205.

2. Prigent SA, et. al. J Biol Chem, 1990, 265(17):9970-7.

3. Soos MA, et. al. Biochem J, 1989, 263(2):553-63.

4. Issad, et. al. Febs Letters, 1992, 296:41-5.



Documents

Manuals & protocols