Thermo Scientific™

Lab Vision™ IGF-1R (α -Subunit) Ab-1, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

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Description

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-31

Isotype: IgG1

Species Reactivity: Human. Weakly reacts with Rabbit. Does not react with rat. Pig unknown.

Epitope: aa 283-440 (exon 4-6)

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation
  • ELISA
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Does Not Significantly Inhibit IGF-1 Binding

Note:

USA: RUO; Int'l: RUO

General References:

1. Soos MA, et. al. Ad Exp Med Biol, 1993, 343:145-57.

2. Soos MA, et. al. Biochem Jl, 1993, 290:419-26.

3. Takahashi et. al. Brit J Cancer, 1995, 72:813-7.

4. Schumacher R, et al. J Bio Chem, 1993, 268:1087-94.

5. Soos MA, et. al. J Bio Chem, 1992, 267:12955-63.



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