Thermo Scientific™

Lab Vision™ IGF-1R (α -Subunit) Ab-4, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Ideal for immunoprecipitation, Thermo Scientific™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

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Description

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-60

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly reacts with Rabbit and Pig (Ab-2 is better). Does not react with rat.

Epitope: aa 184-283

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-4 is excellent for immunoprecipitation of alpha-subunit of IGF-1R.

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Substantially (>80%) Inhibits IGF-1 Binding

Note:

USA: RUO; Int'l: RUO

General References:

1. Schumacher R, et al. J Bio Chem, 1993, 268:1087-94.

2. Takahashi et. al. Brit J Cancer, 1995, 72:813-7.

3. Middleton et. al. J Histochem Cytochem, 1996, 44:133-141.

4. Soos MA, et. al. Ad Exp Med Biol, 1993, 343:145-57.

5. Soos MA, et. al. J Bio Chem, 1992, 267:12955-63.



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