Thermo Scientific™

Lab Vision™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Ensure accurate, reproducible results with the Thermo Scientific™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.
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Multi-drug resistance(MDR) associated p-glycoprotein (p170) causes resistance to various drugs in a number of cancer patients. It exists in a soluble and membrane associated form. Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum. The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein.

Host Species: Mouse

Clone: F4

Isotype: IgG1

Species Reactivity: Human, Chinese Hamster. Does not react with mouse. Others not known.

Epitope: Extracellular amino terminal half. This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to p-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of p-glycoprotein, respectively.

Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes

Molecular Weight: 170kDa

Positive Control: Drug-resistant cells, Kidney or breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Flow Cytometry (Fixed cells only)

Note:

USA: RUO; Int'l: RUO

General References:

1. Chu TM, et. al. Hybridoma, 1993, 12(4):417-29.

2. Chu TM, et. al. Biochemical and Biophysical Research Communications, 1994, 203:506-12.