Thermo Scientific™

Lab Vision™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Recommended for a variety of techniques, Thermo Scientific™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.
Back to top
Major vault protein (MVP) is identical to lung-resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung-resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cell lines indicating a poor response to chemotherapy.

Host Species: Mouse

Clone: 1032

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells

Molecular Weight: 104-110kDa

Positive Control: SKBR-3 cells, Breast tumors

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)
  • Gel Supershift
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

General References:

1. Abbondanza C, et al. J Cell Biol 1998141(6):1301-1310.