EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Host Species: Mouse
Species Reactivity: Human. Does not react with mouse and rat. Others not known.
Epitope: Cytoplasmic domain
Immunogen: Purified EGFR from A431 cells
Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)
Positive Control: A431 cells
Cellular Localization: Membrane
- Western Blotting
- Immunoprecipitation (Native and denatured)
USA: RUO; Int'l: RUO
1. Bjorge JD, et. al. Journal of Biological Chemistry, 1987, 262(14):6615-22.