Thermo Scientific™

Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-15, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-15, Mouse Monoclonal Antibody.

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Description

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: H9B4

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: Cytoplasmic domain

Immunogen: Purified EGFR from A431 cells

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells

Cellular Localization: Membrane

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

General References:

1. Bjorge JD, et. al. Journal of Biological Chemistry, 1987, 262(14):6615-22.



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