Thermo Scientific™

Lab Vision™ Transforming Growth Factor α (TGFα) Ab-1, Mouse Monoclonal Antibody

Related applications:

Anatomical Pathology

Provide accurate, reproducible results with the Thermo Scientific™ Transforming Growth Factor α (TGFα) Ab-1, Mouse Monoclonal Antibody.
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TGFα (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.

Host Species: Mouse

Clone: MF9

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Rat and Mouse. Others not known.

Epitope: C-terminal

Immunogen: A 17-amino acid synthetic peptide from the carboxyl-terminus of rat TGFα

Molecular Weight: 6kDa

Positive Control: Recombinant TGFα protein, A2058 cells

Cellular Localization: Cytoplasmic Ab-1 shows no cross-reaction with EGF and the neuropeptide synenkephalin. Ab-1 is excellent for staining of formalin-fixed, paraffin-embedded tissues. The staining with Ab-1 is completely blocked by the peptide used for raising this antibody.

Recommended for:

  • Western Blotting

Note:

USA: RUO; Int'l: RUO

General References:

1. Kudlow JE, et. al. J Bio Chem, 1989, 264(7):3880-3.

2. Kobrin MS, et. al. Endocrinology, 1987, 121(4):1412-6.

3. Kobrin MS, et. al. J Bio Chem, 1986, 261:14414-9.

4. Kudlow JE, et. al. Endocrinology, 1987, 121(4):1577-9.