HER-3/c-erbB-3 Ab-8, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Recommended for Flow Cytometry, Thermo Scientific™ HER-3/c-erbB-3 Ab-8, Mouse Monoclonal Antibody provides accurate, reproducible results.

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Description

c-erbB-3/HER-3 is the third member of the type I family of growth factor receptors. It binds to ligands in the heregulin family. c-erbB-3 is over-expressed in a variety of tumors including breast, stomach, pancreas, and colon. Heregulin & EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.

Host Species: Mouse

Clone: SGP1

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Epitope: Extracellular domain

Immunogen: HER-3/c-erbB-3 oncoprotein purified from transfected human kidney fibroblasts

Molecular Weight: 185 kDa

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Western Blotting (Not suitable)
  • Flow Cytometry
  • Effect on Heregulin (NDF) Binding (Noninhibitory)

Note:

USA: RUO; Int'l: RUO

General References:

1. Breast, 19954:84-91.

2. British J Cancer, 1994 70:459-465.



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