Thermo Scientific™

Lab Vision™ MMP-10 (Stromelysin-2) Ab-2, Mouse Monoclonal Antibody

 Related applications:
Anatomical Pathology
Ensure accurate, reproducible results in immunohistochemistry and western blotting experiments with the Thermo Scientific™ MMP-10 (Stromelysin-2) Ab-2, Mouse Monoclonal Antibody.

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Description

Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading extracellular matrix. Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The two forms of stromelysin (SL), types 1 (MMP-3) and 2 (MMP-10), share 82% sequence homology, but exhibit differences in cellular synthesis and inducibility by cytokines and growth factors in vitro.

Host Species: Mouse

Clone: IVC5

Isotype: IgG2b

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Human recombinant MMP-10 (stromelysin-2 protein)

Molecular Weight: ∽57kDa (proform) and ∽44kDa (active form)

Positive Control: Conditioned, serum-free medium from (TPA-treated) human large cell lymphoma U937 cells; Placenta; Bladder, breast and ovarian CAs

Cellular Localization: Cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO

General References:

1. Bord S, et al. Bone 199823(1):7-12.

2. Saarialho-Kere UK: Arch Dermatol Res 1998290 Suppl:S47-S54.



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