CDC47/MCM7 Ab-2, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Obtain accurate, reproducible results in Immunohistochemistry, Western Blotting, Immunofluorescence and Immunoprecipitation experiments with Thermo Scientific™ CDC47/MCM7 Ab-2, Mouse Monoclonal Antibody.

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Description

hCDC47 is a human member of the MCM family, which allows DNA to replicate once per cell cycle. In quiescent cells, human MCM7 (hMCM7) mRNA is almost undetectable. Stimulation of cells to enter the cell cycle results in induction of hMCM7 expression. The hCDC47 protein expression and localization is found in nuclei of the proliferative components of normal lymph nodes, bone marrow, epidermis and mucosa. Malignant tumors from several organs contained more nuclear hCDC47-positive cells than their normal counterparts. These results indicate that hCDC47 may play a role in normal and neoplastic cell growth in vivo.

Host Species: Mouse

Clone: 47DC141; same as DCS-141

Isotype: IgG1

Species Reactivity: Human, Mouse, Rat, Dog and Xenopus. Others not known.

Epitope: Not determined

Immunogen: Recombinant hCDC47 protein

Molecular Weight: 80 kDa

Positive Control: MAD109, or PC12 cells, Tonsil or breast cancer

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

General References:

1. Suzuki S, et al. Gene 1998216(1):85-91.

2. Romanowski P, et al. Proc Natl Acad Sci U S A 1996 Sep 1793(19):10189-10194.



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