Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury.
AuthorsBareyre FM, Kerschensteiner M, Misgeld T, Sanes JR
JournalNat Med
PubMed ID16286922
'The rodent corticospinal tract (CST) has been used extensively to investigate regeneration and remodeling of central axons after injury. CST axons are currently visualized after injection of tracer dye, which is invasive, incomplete and prone to variation, and often does not show functionally crucial but numerically minor tract components. Here, ... More
Direction-selective retinal ganglion cells arise from molecularly specified multipotential progenitors.
AuthorsDe la Huerta I, Kim IJ, Voinescu PE, Sanes JR,
JournalProc Natl Acad Sci U S A
PubMed ID23045641
'Single progenitors can give rise to any and all of the main retinal cell types: photoreceptors, interneurons (horizontal, bipolar, and amacrine cells), retinal ganglion cells (RGCs), and glia. Many of these types are divisible into multiple functionally, structurally, and molecularly distinct subtypes (e.g., ~25 for RGCs). It remains unknown when ... More
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.
AuthorsBareyre FM, Garzorz N, Lang C, Misgeld T, Büning H, Kerschensteiner M,
JournalProc Natl Acad Sci U S A
PubMed ID21447717
'In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas axons in the CNS fail to regrow. In neurons of the dorsal root ganglia (DRG), which extend branches to both the PNS and CNS, only a PNS lesion but not a CNS lesion induces axonal growth. How this differential ... More
A synaptic basis for auditory-vocal integration in the songbird.
AuthorsBauer EE, Coleman MJ, Roberts TF, Roy A, Prather JF, Mooney R,
JournalJ Neurosci
PubMed ID18256272
'Songbirds learn to sing by memorizing a tutor song that they then vocally mimic using auditory feedback. This developmental sequence suggests that brain areas that encode auditory memories communicate with brain areas for learned vocal control. In the songbird, the secondary auditory telencephalic region caudal mesopallium (CM) contains neurons that ... More
CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat.
AuthorsOnimaru H, Ikeda K, Kawakami K,
JournalJ Neurosci
PubMed ID19036978
'Phox2b protein is a specific marker for neurons in the parafacial region of the ventral medulla, which are proposed to play a role in central chemoreception and postnatal survival. Mutations of PHOX2B cause congenital central hypoventilation syndrome. However, there have been no reports concerning electrophysiological characteristics of these Phox2b-expressing neurons ... More
Microprisms for in vivo multilayer cortical imaging.
AuthorsChia TH, Levene MJ,
JournalJ Neurophysiol
PubMed ID19494189
'Cortical slices allow for simultaneous imaging of multiple cortical layers. However, slices lack native physiological inputs and outputs. Although in vivo, two-photon imaging preserves the native context, it is typically limited to a depth of <500 microm. In addition, simultaneous imaging of multiple cortical layers is difficult due to the ... More
SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.
AuthorsLilley BN, Krishnaswamy A, Wang Z, Kishi M, Frank E, Sanes JR,
Journal
PubMed ID24395778
Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, ... More
Synaptic plasticity associated with a memory engram in the basolateral amygdala.
AuthorsNonaka A, Toyoda T, Miura Y, Hitora-Imamura N, Naka M, Eguchi M, Yamaguchi S, Ikegaya Y, Matsuki N, Nomura H,
Journal
PubMed ID25009263
Synaptic plasticity is a cellular mechanism putatively underlying learning and memory. However, it is unclear whether learning induces synaptic modification globally or only in a subset of neurons in associated brain regions. In this study, we genetically identified neurons activated during contextual fear learning and separately recorded synaptic efficacy from ... More
Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex.
AuthorsYang W, Carrasquillo Y, Hooks BM, Nerbonne JM, Burkhalter A,
Journal
PubMed ID24174670
Mouse visual cortex is subdivided into multiple distinct, hierarchically organized areas that are interconnected through feedforward (FF) and feedback (FB) pathways. The principal synaptic targets of FF and FB axons that reciprocally interconnect primary visual cortex (V1) with the higher lateromedial extrastriate area (LM) are pyramidal cells (Pyr) and parvalbumin ... More
Properties of a distinct subpopulation of GABAergic commissural interneurons that are part of the locomotor circuitry in the neonatal spinal cord.
Commissural inhibitory interneurons (INs) are integral components of the locomotor circuitry that coordinate left-right motor activity during movements. We have shown that GABA-mediated synaptic transmission plays a key role in generating alternating locomotor-like activity in the mouse spinal cord (Hinckley et al., 2005a). The primary objective of our study was ... More
Modulation of perineuronal nets and parvalbumin with developmental song learning.
AuthorsBalmer TS, Carels VM, Frisch JL, Nick TA,
JournalJ Neurosci
PubMed ID19828802
Neural circuits and behavior are shaped during developmental phases of maximal plasticity known as sensitive or critical periods. Neural correlates of sensory critical periods have been identified, but their roles remain unclear. Factors that define critical periods in sensorimotor circuits and behavior are not known. Birdsong learning in the zebra ... More
Experience-dependent, rapid structural changes in hippocampal pyramidal cell spines.
AuthorsKitanishi T, Ikegaya Y, Matsuki N, Yamada MK,
JournalCereb Cortex
PubMed ID19240139
Morphological changes in dendritic spines may contribute to the fine tuning of neural network connectivity. The relationship between spine morphology and experience-dependent neuronal activity, however, is largely unknown. In the present study, we combined 2 histological analyses to examine this relationship: 1) Measurement of spines of neurons whose morphology was ... More
Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations.
AuthorsFlanagan-Steet H, Fox MA, Meyer D, Sanes JR,
JournalDevelopment
PubMed ID16162647
Synapse formation requires the coordination of pre- and postsynaptic differentiation. An unresolved question is which steps in the process require interactions between pre- and postsynaptic cells, and which proceed cell-autonomously. One current model is that factors released from presynaptic axons organize postsynaptic differentiation directly beneath the nerve terminal. Here, we ... More
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse.
AuthorsMiterko LN, White JJ, Lin T, Brown AM, O'Donovan KJ, Sillitoe RV
JournalNeural Dev
PubMed ID30867000
'Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8'
Age- and a-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.
AuthorsMatsui H, Kenmochi N, Namikawa K
JournalCell Rep
PubMed ID30759385
'Parkinson''s disease (PD) is a neurodegenerative disease characterized by a-synuclein-positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in replicating PD phenotypes using animal models partly limits the understanding of PD and the therapy required. Although PD is strongly associated with aging, most experimental animals may not exhibit ... More
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
AuthorsSong M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y
JournalNat Genet
PubMed ID31367015
'Mutations in gene regulatory elements have been associated with a wide range of complex neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in characterizing their regulatory targets, the ability to identify causal genetic variants has remained limited. To address these constraints, we perform an integrative analysis of chromatin ... More
In utero infection of Zika virus leads to abnormal central nervous system development in mice.
AuthorsZhang W, Tan YW, Yam WK, Tu H, Qiu L, Tan EK, Chu JJH, Zeng L
JournalSci Rep
PubMed ID31086212
'The World Health Organization has declared ZIKA virus (ZIKV) a global public health emergency, prompted by the association of ZIKV infections with severe brain abnormalities in the human fetus. ZIKV preferentially targets human neuronal precursor cells (NPCs) in both monolayer and cortical brain organoid culture systems and stunts their growth. ... More
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations.
AuthorsChen P, Lou S, Huang ZH, Wang Z, Shan QH, Wang Y, Yang Y, Li X, Gong H, Jin Y, Zhang Z, Zhou JN
JournalNeuron
PubMed ID32101698
'In response to stressors, individuals adopt different behavioral styles, which are essential for survival and form the basis of differential susceptibility to stress-related disorders. Corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) have predominantly been studied in behavioral response to stress, while the role of mPFC CRF neurons is poorly ... More
The mouse cortico-basal ganglia-thalamic network.
Authors
JournalNature
PubMed ID34616074
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
Authors
JournalNature
PubMed ID32879486
The mouse cortico-striatal projectome.
Authors
JournalNat Neurosci
PubMed ID27322419
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation.
Authors
JournalNat Neurosci
PubMed ID23995068
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement.
Authors
JournalCell
PubMed ID35245431
A claustrum in reptiles and its role in slow-wave sleep.
Authors
JournalNature
PubMed ID32051589
The hippocampal CA2 region is essential for social memory.
Authors
JournalNature
PubMed ID24572357
Posterior amygdala regulates sexual and aggressive behaviors in male mice.
Authors
JournalNat Neurosci
PubMed ID32719562
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Authors
JournalCell
PubMed ID33740419
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.