Beyond the olfactory bulb: an odotopic map in the forebrain.
AuthorsNikonov AA, Finger TE, Caprio J
JournalProc Natl Acad Sci U S A
PubMed ID16339016
'We report electrophysiological evidence that a simple odotopy, the spatial mapping of different odorants, is maintained above the level of the olfactory bulb (OB). Three classes of biologically relevant odorants for fish are processed in distinct regions of the forebrain (FB) in the channel catfish. Feeding cues, mainly amino acids ... More
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
AuthorsHunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA
JournalProc Natl Acad Sci U S A
PubMed ID14704277
'Parkinson''s disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular pathways underlying its pathogenesis remain uncertain. Here, we show that by eliminating c-Jun N-terminal kinases (JNKs) we can prevent neurodegeneration and improve motor function in an animal model of PD. First, we found that ... More
Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology.
AuthorsBowerman M, Michalski JP, Beauvais A, Murray LM, DeRepentigny Y, Kothary R,
Journal
PubMed ID24497575
Spinal muscular atrophy (SMA) is characterized by motor neuron loss, caused by mutations or deletions in the ubiquitously expressed survival motor neuron 1 (SMN1) gene. We recently identified a novel role for Smn protein in glucose metabolism and pancreatic development in both an intermediate SMA mouse model (Smn(2B/-)) and type ... More
Cortical control of adaptation and sensory relay mode in the thalamus.
AuthorsMease RA, Krieger P, Groh A,
Journal
PubMed ID24748112
A major synaptic input to the thalamus originates from neurons in cortical layer 6 (L6); however, the function of this cortico-thalamic pathway during sensory processing is not well understood. In the mouse whisker system, we found that optogenetic stimulation of L6 in vivo results in a mixture of hyperpolarization and ... More
High-throughput morphometric analysis of individual neurons.
AuthorsWu CC, Reilly JF, Young WG, Morrison JH, Bloom FE
JournalCereb Cortex
PubMed ID15054070
To facilitate high-throughput quantitative analysis of neuronal structure, this study optimized the diOlistic method of whole neuron labeling to examine multiple neurons in fixed brain, and optimized image acquisition parameters to preserve signal for subsequent photoconversion. Fluorescent dye-coated gold particles were successively delivered by helium-powered ejection to 250 microm thick ... More
The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.
AuthorsGhashghaei HT, Weber J, Pevny L, Schmid R, Schwab MH, Lloyd KC, Eisenstat DD, Lai C, Anton ES
JournalProc Natl Acad Sci U S A
PubMed ID16446434
Coordinated regulation of neuronal progenitor differentiation in the subventricular zone (SVZ) is a fundamental feature of adult neurogenesis. However, the molecular control of this process remains mostly undeciphered. Here, we investigate the role of neuregulins (NRGs) in this process and show that a NRG receptor, ErbB4, is primarily expressed by ... More
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.
AuthorsMorinville A, Cahill CM, Aibak H, Rymar VV, Pradhan A, Hoffert C, Mennicken F, Stroh T, Sadikot AF, O'Donnell D, Clarke PB, Collier B, Henry JL, Vincent JP, Beaudet A
JournalJ Neurosci
PubMed ID15201327
An in vivo fluorescent deltorphin (Fluo-DLT) internalization assay was used to assess the distribution and regulation of pharmacologically available delta opioid receptors (deltaORs) in the rat lumbar (L4-5) spinal cord. Under basal conditions, intrathecal injection of Fluo-DLT resulted in the labeling of numerous deltaOR-internalizing neurons throughout dorsal and ventral horns. ... More
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse.
AuthorsMiterko LN, White JJ, Lin T, Brown AM, O'Donovan KJ, Sillitoe RV
JournalNeural Dev
PubMed ID30867000
'Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8'
Age- and a-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.
AuthorsMatsui H, Kenmochi N, Namikawa K
JournalCell Rep
PubMed ID30759385
'Parkinson''s disease (PD) is a neurodegenerative disease characterized by a-synuclein-positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in replicating PD phenotypes using animal models partly limits the understanding of PD and the therapy required. Although PD is strongly associated with aging, most experimental animals may not exhibit ... More
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
AuthorsSong M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y
JournalNat Genet
PubMed ID31367015
'Mutations in gene regulatory elements have been associated with a wide range of complex neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in characterizing their regulatory targets, the ability to identify causal genetic variants has remained limited. To address these constraints, we perform an integrative analysis of chromatin ... More
In utero infection of Zika virus leads to abnormal central nervous system development in mice.
AuthorsZhang W, Tan YW, Yam WK, Tu H, Qiu L, Tan EK, Chu JJH, Zeng L
JournalSci Rep
PubMed ID31086212
'The World Health Organization has declared ZIKA virus (ZIKV) a global public health emergency, prompted by the association of ZIKV infections with severe brain abnormalities in the human fetus. ZIKV preferentially targets human neuronal precursor cells (NPCs) in both monolayer and cortical brain organoid culture systems and stunts their growth. ... More
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations.
AuthorsChen P, Lou S, Huang ZH, Wang Z, Shan QH, Wang Y, Yang Y, Li X, Gong H, Jin Y, Zhang Z, Zhou JN
JournalNeuron
PubMed ID32101698
'In response to stressors, individuals adopt different behavioral styles, which are essential for survival and form the basis of differential susceptibility to stress-related disorders. Corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) have predominantly been studied in behavioral response to stress, while the role of mPFC CRF neurons is poorly ... More
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH.
Authors
JournalNature
PubMed ID30911168
Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.
Authors
JournalNat Commun
PubMed ID34707084
Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans.
Authors
JournalCell Rep
PubMed ID33238113
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Authors
JournalMol Neurodegener
PubMed ID22998728
mTOR-driven neural circuit changes initiate an epileptogenic cascade.
Authors
JournalProg Neurobiol
PubMed ID33309800
Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.
Authors
JournalNature
PubMed ID31534216
Layer-Specific Physiological Features and Interlaminar Interactions in the Primary Visual Cortex of the Mouse.
Authors
JournalNeuron
PubMed ID30635232
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex.