Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons.
AuthorsManent JB, Jorquera I, Ben-Ari Y, Aniksztejn L, Represa A,
JournalJ Neurosci
PubMed ID16738232
'Paracrine GABA and glutamate acting, respectively, on GABAA and NMDA receptors modulate the migration of hippocampal pyramidal cells. Using corticohippocampal organotypic explants from glutamic acid decarboxylase (GAD) 67-enhanced green fluorescent protein (EGFP) knock-in embryos, we now report that, in contrast to pyramidal neurons, the blockade of AMPA but not NMDA ... More
Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.
'Activation of the hippocampal dopamine 1-class receptors (D1R and D5R) are implicated in contextual fear conditioning (CFC). However, the specific role of the D1R versus D5R in hippocampal dependent CFC has not been investigated. Generation of D1R- and D5R-specific in situ hybridization probes showed that D1R and D5R mRNA expression ... More
Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain.
AuthorsSosunov AA, Wu X, Tsankova NM, Guilfoyle E, McKhann GM, Goldman JE,
Journal
PubMed ID24501367
'To examine the diversity of astrocytes in the human brain, we immunostained surgical specimens of temporal cortex and hippocampus and autopsy brains for CD44, a plasma membrane protein and extracellular matrix receptor. CD44 antibodies outline the details of astrocyte morphology to a degree not possible with glial fibrillary acidic protein ... More
Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo.
AuthorsZemmar A, Weinmann O, Kellner Y, Yu X, Vicente R, Gullo M, Kasper H, Lussi K, Ristic Z, Luft AR, Rioult-Pedotti M, Zuo Y, Zagrebelsky M, Schwab ME,
Journal
PubMed ID24966370
The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. ... More
Superficially projecting principal neurons in layer V of medial entorhinal cortex in the rat receive excitatory retrosplenial input.
Principal cells in layer V of the medial entorhinal cortex (MEC) have a nodal position in the cortical-hippocampal network. They are the main recipients of hippocampal output and receive inputs from several cortical areas, including a prominent one from the retrosplenial cortex (RSC), likely targeting basal dendrites of layer V ... More
Independent circuits in the basal ganglia for the evaluation and selection of actions.
AuthorsStephenson-Jones M, Kardamakis AA, Robertson B, Grillner S,
Journal
PubMed ID24003130
The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry for selection is well understood, how these nuclei evaluate the outcome of actions is unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates the habenula-projecting globus pallidus (GPh) neurons, exists within ... More
Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus.
AuthorsKunze A, Congreso MR, Hartmann C, Wallraff-Beck A, Hüttmann K, Bedner P, Requardt R, Seifert G, Redecker C, Willecke K, Hofmann A, Pfeifer A, Theis M, Steinhäuser C,
JournalProc Natl Acad Sci U S A
PubMed ID19549869
In the adult dentate gyrus, radial glia-like cells represent putative stem cells generating neurons and glial cells. Here, we combined patch-clamp recordings, biocytin filling, immunohistochemistry, single-cell transcript analysis, and mouse transgenics to test for connexin expression and gap junctional coupling of radial glia-like cells and its impact on neurogenesis. Radial ... More
Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain.
AuthorsStorek B, Reinhardt M, Wang C, Janssen WG, Harder NM, Banck MS, Morrison JH, Beutler AS,
JournalProc Natl Acad Sci U S A
PubMed ID18215993
Lumbar puncture (LP) is an attractive route to deliver drugs to the nervous system because it is a safe bedside procedure. Its use for gene therapy has been complicated by poor vector performance and failure to target neurons. Here we report highly effective gene transfer to the primary sensory neurons ... More
Astroglial connexin immunoreactivity is specifically altered at ß-amyloid plaques in ß-amyloid precursor protein/presenilin1 mice.
AuthorsMei X, Ezan P, Giaume C, Koulakoff A,
JournalNeuroscience
PubMed ID20813165
Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease (AD) with consequences yet poorly understood. Astrocytes are characterized by a high level of intercellular communication mediated by two gap-junction forming proteins, connexin-43 and connexin-30. As astroglial connexins (Cxs) are involved in neuronal dysfunctions and death, we have ... More
In vivo imaging of axonal degeneration and regeneration in the injured spinal cord.
AuthorsKerschensteiner M, Schwab ME, Lichtman JW, Misgeld T
JournalNat Med
PubMed ID15821747
The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury. Here, we monitor individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury. We find that within 30 min after trauma, axons die back hundreds of micrometers. ... More
Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism.
Authors
JournalNat Commun
PubMed ID35082287
The participation of cortical amygdala in innate, odour-driven behaviour.
Authors
JournalNature
PubMed ID25383519
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.
Authors
JournalNat Neurosci
PubMed ID28530662
Multiomic profiling of the acute stress response in the mouse hippocampus.
Authors
JournalNat Commun
PubMed ID35383160
Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons.
Authors
JournalNat Commun
PubMed ID34059686
Grid cells are modulated by local head direction.
Authors
JournalNat Commun
PubMed ID32839445
STING controls nociception via type I interferon signalling in sensory neurons.
Authors
JournalNature
PubMed ID33442058
The hippocampal CA2 region is essential for social memory.
Authors
JournalNature
PubMed ID24572357
Microbiota modulate sympathetic neurons via a gut-brain circuit.
Authors
JournalNature
PubMed ID32641826
Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues.